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Year Number of Results
2004 2
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2008 1
2010 2
2011 1
2012 1
2013 1
2014 4
2015 1
2016 2
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2019 1
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2022 1
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22 results

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Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer.
Dunn NR, Tolwinski NS. Dunn NR, et al. Cancers (Basel). 2016 Jul 16;8(7):68. doi: 10.3390/cancers8070068. Cancers (Basel). 2016. PMID: 27438854 Free PMC article. Review.
Human development uses a remarkably small number of signal transduction pathways to organize vastly complicated tissues. These pathways are commonly associated with disease in adults if activated inappropriately. ...We will summarize work from our laboratories as well as m …
Human development uses a remarkably small number of signal transduction pathways to organize vastly complicated tissues. These pathwa …
PTK7 Faces the Wnt in Development and Disease.
Berger H, Wodarz A, Borchers A. Berger H, et al. Front Cell Dev Biol. 2017 Apr 5;5:31. doi: 10.3389/fcell.2017.00031. eCollection 2017. Front Cell Dev Biol. 2017. PMID: 28424771 Free PMC article. Review.
PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor regulating various processes in embryonic development and tissue homeostasis. ...Here we will review recent findings implicating PTK7 at the crossroads of Wnt signal …
PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor regulating various processes in embryonic …
PTK7 localization and protein stability is affected by canonical Wnt ligands.
Berger H, Breuer M, Peradziryi H, Podleschny M, Jacob R, Borchers A. Berger H, et al. J Cell Sci. 2017 Jun 1;130(11):1890-1903. doi: 10.1242/jcs.198580. Epub 2017 Apr 18. J Cell Sci. 2017. PMID: 28420671
Protein tyrosine kinase 7 (PTK7) is an evolutionarily conserved transmembrane receptor with important roles in embryonic development and disease. ...PTK7 endocytosis is dependent on the presence of the PTK7 co-receptor Fz7 (also known as Fzd7) and resu …
Protein tyrosine kinase 7 (PTK7) is an evolutionarily conserved transmembrane receptor with important roles in embryonic devel …
Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis.
Golubkov VS, Prigozhina NL, Zhang Y, Stoletov K, Lewis JD, Schwartz PE, Hoffman RM, Strongin AY. Golubkov VS, et al. J Biol Chem. 2014 Aug 29;289(35):24238-49. doi: 10.1074/jbc.M114.574459. Epub 2014 Jul 8. J Biol Chem. 2014. PMID: 25006253 Free PMC article.
It is well established that widely expressed PTK7 is essential for vertebrate tissue morphogenesis. In cancer, the functionality of PTK7 is selectively regulated by membrane type-1 matrix metalloproteinase (MT1-MMP), ADAMs (a disintegrin domain and metallopro …
It is well established that widely expressed PTK7 is essential for vertebrate tissue morphogenesis. In cancer, the functionali …
New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome.
Raivola J, Dini A, Salokas K, Karvonen H, Niininen W, Piki E, Varjosalo M, Ungureanu D. Raivola J, et al. Cell Mol Life Sci. 2022 May 4;79(5):276. doi: 10.1007/s00018-022-04301-6. Cell Mol Life Sci. 2022. PMID: 35504983 Free PMC article.
ROR1, ROR2, and PTK7 are Wnt ligand-binding members of the receptor tyrosine kinase family. Despite their lack of catalytic activity, these receptors regulate skeletal, cardiorespiratory, and neurological development during embryonic and fetal stages. However, their …
ROR1, ROR2, and PTK7 are Wnt ligand-binding members of the receptor tyrosine kinase family. Despite their lack of catalytic activity, …
Ptk7 Is Dynamically Localized at Neural Crest Cell-Cell Contact Sites and Functions in Contact Inhibition of Locomotion.
Grund A, Till K, Giehl K, Borchers A. Grund A, et al. Int J Mol Sci. 2021 Aug 28;22(17):9324. doi: 10.3390/ijms22179324. Int J Mol Sci. 2021. PMID: 34502237 Free PMC article.
Conversely, we found that ectopic expression of Ptk7 in non-NC cells was able to prevent NC cell invasion. However, deletion of the extracellular domains of Ptk7 abolished this effect. Thus, Ptk7 is sufficient at protecting non-NC tissue from NC cell i …
Conversely, we found that ectopic expression of Ptk7 in non-NC cells was able to prevent NC cell invasion. However, deletion of the e …
The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway.
Martinez S, Scerbo P, Giordano M, Daulat AM, Lhoumeau AC, Thomé V, Kodjabachian L, Borg JP. Martinez S, et al. J Biol Chem. 2015 Dec 18;290(51):30562-72. doi: 10.1074/jbc.M115.697615. Epub 2015 Oct 23. J Biol Chem. 2015. PMID: 26499793 Free PMC article.
Furthermore, we show that Ptk7 is required for papc activation induced by Wnt5a. Interestingly, we find that Wnt5a stimulates the release of the tagged Ptk7 intracellular domain, which can translocate into the nucleus and activate papc expression. This study reveals …
Furthermore, we show that Ptk7 is required for papc activation induced by Wnt5a. Interestingly, we find that Wnt5a stimulates the rel …
The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility.
Linnemannstöns K, Ripp C, Honemann-Capito M, Brechtel-Curth K, Hedderich M, Wodarz A. Linnemannstöns K, et al. PLoS Genet. 2014 Jul 10;10(7):e1004443. doi: 10.1371/journal.pgen.1004443. eCollection 2014 Jul. PLoS Genet. 2014. PMID: 25010066 Free PMC article.
Wnt proteins regulate many developmental processes and are required for tissue homeostasis in adult animals. The cellular responses to Wnts are manifold and are determined by the respective Wnt ligand and its specific receptor complex in the plasma membrane. ...We found th …
Wnt proteins regulate many developmental processes and are required for tissue homeostasis in adult animals. The cellular responses t …
PlexinA1 interacts with PTK7 and is required for neural crest migration.
Wagner G, Peradziryi H, Wehner P, Borchers A. Wagner G, et al. Biochem Biophys Res Commun. 2010 Nov 12;402(2):402-7. doi: 10.1016/j.bbrc.2010.10.044. Epub 2010 Oct 12. Biochem Biophys Res Commun. 2010. PMID: 20946874
PlexinA1 likely affects neural crest migration by interaction with PTK7, a regulator of planar cell polarity that is required for neural crest migration. PlexinA1 and PTK7 interact in immunoprecipitation assays and show phenotypic interaction in co-injection experim …
PlexinA1 likely affects neural crest migration by interaction with PTK7, a regulator of planar cell polarity that is required for neu …
The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.
Paudyal A, Damrau C, Patterson VL, Ermakov A, Formstone C, Lalanne Z, Wells S, Lu X, Norris DP, Dean CH, Henderson DJ, Murdoch JN. Paudyal A, et al. BMC Dev Biol. 2010 Aug 12;10:87. doi: 10.1186/1471-213X-10-87. BMC Dev Biol. 2010. PMID: 20704721 Free PMC article.
We demonstrate that chuzhoi maps to Chromosome 17 and carries a splice site mutation in Ptk7. This mutation results in the insertion of three amino acids into the Ptk7 protein and causes disruption of Ptk7 protein expression in chuzhoi mutants. ...The chuzhoi …
We demonstrate that chuzhoi maps to Chromosome 17 and carries a splice site mutation in Ptk7. This mutation results in the insertion …
22 results